Dual Arm Factorial Randomized Trial in Patients w/ST Segment Elevation AMI to Compare the Results of Using Anticoagulation With Either Unfractionated Heparin + Routine GP IIb/IIIa Inhibition or Bivalirudin + Bail-out GP IIb/IIIa Inhibition; and Primary Angioplasty With Stent Implantation With Either a Slow Rate-release Paclitaxel-eluting Stent (TAXUS) or Uncoated Bare Metal Stent (EXPRESS2)

Trial Profile

Dual Arm Factorial Randomized Trial in Patients w/ST Segment Elevation AMI to Compare the Results of Using Anticoagulation With Either Unfractionated Heparin + Routine GP IIb/IIIa Inhibition or Bivalirudin + Bail-out GP IIb/IIIa Inhibition; and Primary Angioplasty With Stent Implantation With Either a Slow Rate-release Paclitaxel-eluting Stent (TAXUS) or Uncoated Bare Metal Stent (EXPRESS2)

Completed
Phase of Trial: Phase III

Latest Information Update: 06 Dec 2017

At a glance

  • Drugs Bivalirudin (Primary) ; Paclitaxel (Primary) ; Abciximab; Eptifibatide; Heparin; Tirofiban
  • Indications Coronary artery restenosis; Myocardial infarction; Stent thrombosis; Thrombosis
  • Focus Adverse reactions; Registrational; Therapeutic Use
  • Acronyms HORIZONS-AMI; HORIZONS-AMI CMRI
  • Most Recent Events

    • 01 Dec 2017 Results of age-based subgroup analysis assessing the effect of bivalirudin versus heparin using 30-day pooled data (n=5800) from the two large randomized trials (EUROMAX and HORIZONS-AMI), published in the American Heart Journal.
    • 29 Mar 2017 Results of comparison of outcomes and prognostic factor in patients with versus without newly diagnosed daibetes mellitus published in the American Journal of Cardiology
    • 20 Apr 2016 Results of a pooled analysis from REPLACE-2, ACUITY and HORIZONS-AMI Trials (n=3641) published in the American Journal of Cardiology
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