A randomized, open-label, 3-period crossover study to evaluate the effect of multiple doses of DVS SR [desvenlafaxine sustained release] and paroxetine on the CYP2D6 biotransformation of codeine to morphine in healthy subjects

Trial Profile

A randomized, open-label, 3-period crossover study to evaluate the effect of multiple doses of DVS SR [desvenlafaxine sustained release] and paroxetine on the CYP2D6 biotransformation of codeine to morphine in healthy subjects

Completed
Phase of Trial: Phase I

Latest Information Update: 20 May 2009

At a glance

  • Drugs Codeine; Desvenlafaxine; Paroxetine
  • Indications Anxiety; Depression; Depressive disorders; Pain
  • Focus Pharmacokinetics
  • Sponsors Wyeth
  • Most Recent Events

    • 20 May 2009 Results presented at the 162nd Annual Meeting of the American Psychiatric Association (APA 2009).
    • 17 Apr 2007 New trial record.
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