A Phase 3 Randomized, Rater-Blinded Study Comparing Two Annual Cycles of Intravenous Alemtuzumab to Three-Times Weekly Subcutaneous Interferon Beta-1a (Rebif) in Treatment-Naive Patients With Relapsing-Remitting Multiple Sclerosis

Trial Profile

A Phase 3 Randomized, Rater-Blinded Study Comparing Two Annual Cycles of Intravenous Alemtuzumab to Three-Times Weekly Subcutaneous Interferon Beta-1a (Rebif) in Treatment-Naive Patients With Relapsing-Remitting Multiple Sclerosis

Completed
Phase of Trial: Phase III

Latest Information Update: 23 Aug 2017

At a glance

  • Drugs Alemtuzumab (Primary) ; Interferon beta-1a
  • Indications Multiple sclerosis
  • Focus Registrational; Therapeutic Use
  • Acronyms CARE-MS-I
  • Sponsors Genzyme Corporation
  • Most Recent Events

    • 23 Aug 2017 Results assessing 5-year follow up outcomes in patients completing CARE-MS I and enrolling in the extension study published in the Neurology.
    • 27 Jun 2017 Results of pooled analysis of NCT00530348, NCT00548405 and NCT00930553 trials assessing conversion from RRMS to SPMS presented at the 3rd Congress of the European Academy of Neurology
    • 27 Jun 2017 Results of post hoc pooled analysis comparing efficacy of alemtuzumab and ocrelizumab based on number needed to treat (NNT) from CAMMS223,CARE-MS I, CARE-MS II and OPERA I and II studies,presented at the 3rd Congress of the European Academy of Neurology.
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