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Phase III, multicenter, European, randomized trial comparing the combination Fludarabine-Cyclophosphamide-Rituximab (FCR) with the combination Fludarabine-Cyclophosphamide-Campath (FCCam) in previously untreated adults with B and C Binet stage B-chronic lymphoid leukemia (B-CLL).

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Trial Profile

Phase III, multicenter, European, randomized trial comparing the combination Fludarabine-Cyclophosphamide-Rituximab (FCR) with the combination Fludarabine-Cyclophosphamide-Campath (FCCam) in previously untreated adults with B and C Binet stage B-chronic lymphoid leukemia (B-CLL).

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 04 Apr 2016

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At a glance

  • Drugs Rituximab (Primary) ; Alemtuzumab; Cyclophosphamide; Fludarabine
  • Indications Chronic lymphocytic leukaemia
  • Focus Therapeutic Use

    • Most Recent Events

    • 14 Feb 2012 Primary endpoint 'Progression-free-survival' has not been met.
    • 14 Feb 2012 Results published in the Blood.
    • 10 Dec 2011 Minimal residual disease monitoring outcomes at month 9 using a sensitive 6-color flow cytometry technique have been reported at the 53rd Annual Meeting and Expostion of the American Society of Hematology.
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