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A Phase 1 Dose Escalation Trial to Determine the Safety, Tolerability and Maximum Tolerated Dose of Oral AP24534 in Patients with Refractory or Advanced Chronic Myelogenous Leukemia and other Hematologic Malignancies (AP24534-07-101)

Trial Profile

A Phase 1 Dose Escalation Trial to Determine the Safety, Tolerability and Maximum Tolerated Dose of Oral AP24534 in Patients with Refractory or Advanced Chronic Myelogenous Leukemia and other Hematologic Malignancies (AP24534-07-101)

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 09 Nov 2021

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At a glance

  • Drugs Ponatinib (Primary)
  • Indications Acute myeloid leukaemia; Chronic myeloid leukaemia; Haematological malignancies; Precursor cell lymphoblastic leukaemia-lymphoma
  • Focus Adverse reactions
  • Sponsors ARIAD Pharmaceuticals
  • Most Recent Events

    • 01 Jun 2017 Status changed from active, no longer recruiting to completed.
    • 06 Dec 2016 Results of pooled analysis (n=76, data cut-off-2 Feb 2015) of a subgroup of chronic phase -chronic myelogenous leukemia patients from the phase 1 (NCT00660920) and pivotal phase 2 PACE (NCT01207440) trials, presented at the 58th Annual Meeting and Exposition of the American Society of Hematology.
    • 06 Dec 2016 Results presented at the 58th Annual Meeting and Exposition of the American Society of Hematology
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