An Open-Label, Multicenter Dose-Escalation Study to Evaluate the Safety and Tolerability of AP 12009 (Trabedersen), Administered Intravenously in Patients With Advanced Tumors Known to Overproduce TGF-beta2.

Trial Profile

An Open-Label, Multicenter Dose-Escalation Study to Evaluate the Safety and Tolerability of AP 12009 (Trabedersen), Administered Intravenously in Patients With Advanced Tumors Known to Overproduce TGF-beta2.

Completed
Phase of Trial: Phase I/II

Latest Information Update: 12 Sep 2017

At a glance

  • Drugs Trabedersen (Primary)
  • Indications Colorectal cancer; Malignant melanoma; Pancreatic cancer
  • Focus Adverse reactions
  • Sponsors Isarna Therapeutics
  • Most Recent Events

    • 12 Sep 2017 Results assessing the association between plasma levels of cyto-/chemokines and overall survival (OS) outcomes to identify potential biomarkers for improved OS presented at the 42nd European Society for Medical Oncology Congress.
    • 12 Sep 2017 Results of population pharmacokinetic model to evaluate factors contributing to the variability in PK of Trabedersen presented at the 42nd European Society for Medical Oncology Congress
    • 06 Jun 2017 Results of phase II portion of this study (n=37) presented at the 53rd Annual Meeting of the American Society of Clinical Oncology
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