A Randomized Double-Blind, Placebo-Controlled Study of Everolimus in Combination With Exemestane in the Treatment of Postmenopausal Women With Estrogen Receptor-Positive Locally Advanced or Metastatic Breast Cancer Who Are Refractory to Letrozole or Anastrozole.

Trial Profile

A Randomized Double-Blind, Placebo-Controlled Study of Everolimus in Combination With Exemestane in the Treatment of Postmenopausal Women With Estrogen Receptor-Positive Locally Advanced or Metastatic Breast Cancer Who Are Refractory to Letrozole or Anastrozole.

Completed
Phase of Trial: Phase III

Latest Information Update: 09 Dec 2017

At a glance

  • Drugs Everolimus (Primary) ; Exemestane
  • Indications Advanced breast cancer; Bone metastases
  • Focus Registrational; Therapeutic Use
  • Acronyms BOLERO-2
  • Sponsors Novartis; Novartis Pharmaceuticals Corporation
  • Most Recent Events

    • 09 Dec 2017 Results assessing the prognostic and predictive ability of activin A (n=513) presented at the 40th Annual San Antonio Breast Cancer Symposium
    • 10 Jun 2017 Biomarkers information updated
    • 09 Feb 2017 Results assessing impact of PIK3CA mutations on everolimus efficacy published in the British Journal of Cancer.
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