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Phase 3, Randomized, Open-label Study Of The Efficacy And Safety Of Pf-02341066 Versus Standard Of Care Chemotherapy (Pemetrexed Or Docetaxel) In Patients With Advanced Non-small Cell Lung Cancer (Nsclc) Harboring A Translocation Or Inversion Event Involving The Anaplastic Lymphoma Kinase (Alk) Gene Locus

Trial Profile

Phase 3, Randomized, Open-label Study Of The Efficacy And Safety Of Pf-02341066 Versus Standard Of Care Chemotherapy (Pemetrexed Or Docetaxel) In Patients With Advanced Non-small Cell Lung Cancer (Nsclc) Harboring A Translocation Or Inversion Event Involving The Anaplastic Lymphoma Kinase (Alk) Gene Locus

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 20 Dec 2021

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At a glance

  • Drugs Crizotinib (Primary) ; Docetaxel; Pemetrexed
  • Indications Non-small cell lung cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms P1007; PROFILE 1007; PROFILE-1007
  • Sponsors Pfizer
  • Most Recent Events

    • 26 Feb 2019 Results of pooled analysis (data cutoff date 15 July 2014) of four clinical trials (NCT00585195,NCT00932451,NCT00932893 and NCT01154140) evaluating renal effects of crizotinib in patients with advanced Non-Small Cell Lung Cancer published in the Journal of Thoracic Oncology
    • 13 Jul 2018 Results assessing Crizotinib efficacy in three prospective studies ((PROFILE 1005, PROFILE 1007, and PROFILE 1014), were published in the Annals of Oncology.
    • 18 Oct 2017 Results of analysis assessing the effect of dexamethasone on steady-state crizotinib exposure using patient data from PROFILE-1001, PROFILE-1005, PROFILE-1007, PROFILE-1014 trials presented at the 18th World Conference on Lung Cancer
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