Phase 2, Open-label Single Arm Study Of The Efficacy And Safety Of Pf-02341066 In Patients With Advanced Non-small Cell Lung Cancer (Nsclc) Harboring A Translocation Or Inversion Involving The Anaplastic Lymphoma Kinase (Alk) Gene Locus

Trial Profile

Phase 2, Open-label Single Arm Study Of The Efficacy And Safety Of Pf-02341066 In Patients With Advanced Non-small Cell Lung Cancer (Nsclc) Harboring A Translocation Or Inversion Involving The Anaplastic Lymphoma Kinase (Alk) Gene Locus

Completed
Phase of Trial: Phase II

Latest Information Update: 18 Oct 2017

At a glance

  • Drugs Crizotinib (Primary)
  • Indications Brain metastases; Non-small cell lung cancer
  • Focus Adverse reactions; Therapeutic Use
  • Acronyms P1005; PROFILE-1005
  • Sponsors Pfizer
  • Most Recent Events

    • 18 Oct 2017 Results assessing the mechanisms of intrinsic resistance to crizotinib through a targeted cancer gene panel of next-generation sequencing (n=47), presented at the 18th World Conference on Lung Cancer
    • 18 Oct 2017 Results of analysis assessing the effect of dexamethasone on steady-state crizotinib exposure using patient data from PROFILE-1001, PROFILE-1005, PROFILE-1007, PROFILE-1014 trials presented at the 18th World Conference on Lung Cancer
    • 10 Jun 2017 Biomarkers information updated
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