A Randomized Phase II Study of Two Dose-Levels of Vorinostat in Combination With 5-FU and Leucovorin in Patients With Refractory Metastatic Colorectal Cancer.

Trial Profile

A Randomized Phase II Study of Two Dose-Levels of Vorinostat in Combination With 5-FU and Leucovorin in Patients With Refractory Metastatic Colorectal Cancer.

Completed
Phase of Trial: Phase II

Latest Information Update: 20 Sep 2012

At a glance

  • Drugs Vorinostat (Primary) ; Fluorouracil; Folinic acid
  • Indications Colorectal cancer
  • Focus Therapeutic Use
  • Most Recent Events

    • 27 Mar 2012 Status changed from active, no longer recruiting to completed as reported by ClinicalTrials.gov.
    • 27 Sep 2011 Results presented at the 2011 European Multidisciplinary Cancer Congress.
    • 27 Sep 2011 Eight of 15 patients had disease control in the high-dose arm and the arm was closed to accrual; whereas, 9 of 15 patients had disease control in the low-dose arm and accrual was expanded to 43 patients.
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