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Phase III trial in patients with multiple myeloma to optimize bortezomib based induction (bortezomib, Adriamycin, dexamethasone [PAd] vs. bortezomib, cyclophosphamide, dexamethasone [VCD]) prior to high dose therapy and autologous stem cell transplantation followed by lenalidomide based consolidation and maintenance therapy.

Trial Profile

Phase III trial in patients with multiple myeloma to optimize bortezomib based induction (bortezomib, Adriamycin, dexamethasone [PAd] vs. bortezomib, cyclophosphamide, dexamethasone [VCD]) prior to high dose therapy and autologous stem cell transplantation followed by lenalidomide based consolidation and maintenance therapy.

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 24 Jan 2023

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At a glance

  • Drugs Bortezomib (Primary) ; Bortezomib (Primary) ; Cyclophosphamide; Dexamethasone; Doxorubicin; Lenalidomide; Melphalan
  • Indications Multiple myeloma
  • Focus Registrational; Therapeutic Use
  • Acronyms MM5
  • Most Recent Events

    • 13 Dec 2022 Results defining implications and prognostic value of MS in a large cohort of transplant eligible patients with newly diagnosed MM treated within the phase 3 multicenter GMMG MM5 trial presented at the 64th American Society of Hematology Annual Meeting and Exposition
    • 14 Dec 2021 Results of Intergroup Analysis from phase III trials, HD4, MM5 and HD6 and European Myeloma Network (EMN) 02/ Dutch-Belgian Cooperative Trial Group for Hematology Oncology Foundation (HOVON) 95 presented at the 63rd American Society of Hematology Annual Meeting and Exposition
    • 01 Mar 2021 Results of an exploratory subgroup analysis with focus on progression free survival (PFS), overall survival (OS), time to progression (TTP), non relapse mortality (NRM), response rates and toxicities with regard to patient age at randomization published in the Leukemia
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