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A Phase IIa, Double-blind, Randomized, 2-way Cross-over Study to Evaluate the Effect of a Single Dose of AZD1386 95 mg Compared to Placebo in a Multimodal Experimental Pain Model on Esophageal Sensitivity in GERD Patients With a Partial Response to PPI Treatment.

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Trial Profile

A Phase IIa, Double-blind, Randomized, 2-way Cross-over Study to Evaluate the Effect of a Single Dose of AZD1386 95 mg Compared to Placebo in a Multimodal Experimental Pain Model on Esophageal Sensitivity in GERD Patients With a Partial Response to PPI Treatment.

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 09 Jun 2021

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At a glance

  • Drugs AZD 1386 (Primary)
  • Indications Visceral pain
  • Focus Pharmacogenomic; Therapeutic Use
  • Sponsors AstraZeneca

    • Most Recent Events

    • 15 Jun 2012 Planned number of patients changed from 27 to 30.
    • 19 May 2012 Primary endpoint 'Pain-measures' has not been met.
    • 19 May 2012 Results presented at the Digestive Disease Week 2012.
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