A Phase 1 Dose Escalation Study of MLN8237, an Aurora A Kinase Inhibitor, in Adult Patients With Nonhematological Malignancies, Followed by a Phase 2 of MLN8237 in Lung, Breast, Head and Neck, or Gastroesophageal Malignancies.

Trial Profile

A Phase 1 Dose Escalation Study of MLN8237, an Aurora A Kinase Inhibitor, in Adult Patients With Nonhematological Malignancies, Followed by a Phase 2 of MLN8237 in Lung, Breast, Head and Neck, or Gastroesophageal Malignancies.

Completed
Phase of Trial: Phase I/II

Latest Information Update: 16 Aug 2016

At a glance

  • Drugs Alisertib (Primary)
  • Indications Advanced breast cancer; Gastric cancer; Head and neck cancer; Non-small cell lung cancer; Oesophageal cancer; Small cell lung cancer; Solid tumours
  • Focus Adverse reactions; Biomarker; Therapeutic Use
  • Sponsors Millennium
  • Most Recent Events

    • 07 Jun 2017 Biomarkers information updated
    • 14 Dec 2013 Phase II results for breast cancer patients presented at the 36th Annual San Antonio Breast Cancer Symposium.
    • 28 Jun 2013 Planned end date changed from 1 Nov 2013 to 1 Jul 2013 as reported by ClinicalTrials.gov.
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