Phase-II, Randomized, Multicentre Pilot Study to Evaluate the Safety and Efficacy of the Treatment With mFOLFOX-6 Plus Cetuximab Versus Initial Treatment With mFOLFOX-6 Plus Cetuximab (for 8 Cycles), Followed by Maintenance With Cetuximab Alone as First-line Treatment in Patients With Metastatic Colorectal Cancer (mCRC) and Wild-type KRAS Tumours.

Trial Profile

Phase-II, Randomized, Multicentre Pilot Study to Evaluate the Safety and Efficacy of the Treatment With mFOLFOX-6 Plus Cetuximab Versus Initial Treatment With mFOLFOX-6 Plus Cetuximab (for 8 Cycles), Followed by Maintenance With Cetuximab Alone as First-line Treatment in Patients With Metastatic Colorectal Cancer (mCRC) and Wild-type KRAS Tumours.

Completed
Phase of Trial: Phase II

Latest Information Update: 12 Sep 2017

At a glance

  • Drugs Cetuximab (Primary) ; Fluorouracil; Folinic acid; Folinic acid; Oxaliplatin
  • Indications Colorectal cancer
  • Focus Therapeutic Use
  • Acronyms MACRO-2
  • Most Recent Events

    • 12 Sep 2017 Results of pooled data from two trial (MACRO-2 and PLANET) assessing the impact of tumor location on the efficacy of first line anti-EGFR monoclonal antibody plus chemotherapy in patients with metastatic colorectal cancer, were presented at the 42nd European Society for Medical Oncology Congress.
    • 24 Jul 2015 Status changed from active, no longer recruiting to completed as reported by ClinicalTrials.gov
    • 19 Feb 2013 Status changed from recruiting to active, no longer recruiting as reported by ClinicalTrials.gov.
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