A Randomized, Double-Blind, Multicenter Phase 3 Study of Irinotecan, Folinic Acid, and 5-Fluorouracil (FOLFIRI) Plus Ramucirumab or Placebo in Patients With Metastatic Colorectal Carcinoma Progressive During or Following First-Line Combination Therapy With Bevacizumab, Oxaliplatin, and a Fluoropyrimidine

Trial Profile

A Randomized, Double-Blind, Multicenter Phase 3 Study of Irinotecan, Folinic Acid, and 5-Fluorouracil (FOLFIRI) Plus Ramucirumab or Placebo in Patients With Metastatic Colorectal Carcinoma Progressive During or Following First-Line Combination Therapy With Bevacizumab, Oxaliplatin, and a Fluoropyrimidine

Completed
Phase of Trial: Phase III

Latest Information Update: 13 Jul 2017

At a glance

  • Drugs Ramucirumab (Primary) ; Fluorouracil; Folinic acid; Irinotecan
  • Indications Colorectal cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms RAISE
  • Sponsors Eli Lilly
  • Most Recent Events

    • 21 Jan 2017 Results (n=1012) of post hoc subgroup analysis (L-CRC and R-CRC) assessing effect of tumour location on efficacy of treatment, presented at the 2017 Gastrointestinal Cancers Symposium
    • 01 Nov 2016 Results of subgroup analysis published in the Annals of Oncology
    • 11 Oct 2016 Results of exploratory analysis presented at the 41st European Society for Medical Oncology Congress.
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