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A Phase IIb, Randomized, Double-Blind, Placebo-Controlled, Active Controlled, Parallel Group, Multicenter Study to Assess the Safety and Efficacy of 2 Fixed Dose Groups of TC-5214 (S-mecamylamine) as Monotherapy Treatment in Patients With Major Depressive Disorder Who Exhibit an Inadequate Response to Antidepressant Therapy.

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Trial Profile

A Phase IIb, Randomized, Double-Blind, Placebo-Controlled, Active Controlled, Parallel Group, Multicenter Study to Assess the Safety and Efficacy of 2 Fixed Dose Groups of TC-5214 (S-mecamylamine) as Monotherapy Treatment in Patients With Major Depressive Disorder Who Exhibit an Inadequate Response to Antidepressant Therapy.

Status: Discontinued
Phase of Trial: Phase II

Latest Information Update: 24 Sep 2018

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At a glance

  • Drugs Dexmecamylamine (Primary) ; Duloxetine
  • Indications Major depressive disorder
  • Focus Therapeutic Use
  • Acronyms EXPLORER
  • Sponsors AstraZeneca

    • Most Recent Events

    • 09 May 2012 Additional lead trial investigator added as reported by Clinical Trials Registry - India.
    • 11 Apr 2012 Status changed from recruiting to discontinued as reported by ClinicalTrials.gov.
    • 23 Nov 2011 New source identified and integrated (Clinical Trials Registry - India record, CTRI2011-10-002065).
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