Optimized Phase III Trial of Immuno-stimulation With Maraviroc, a CCR5 (Chemokine Receptor 5) Antagonist, Combined With Anti Retroviral Therapy in Advanced, Late Diagnosed HIV-1 Infected Patients With an AIDS-defining Event and/or CD4 (Cluster of Differentiation 4) Counts Below 200 Cells/mm³. ANRS 146 OPTIMAL.

Trial Profile

Optimized Phase III Trial of Immuno-stimulation With Maraviroc, a CCR5 (Chemokine Receptor 5) Antagonist, Combined With Anti Retroviral Therapy in Advanced, Late Diagnosed HIV-1 Infected Patients With an AIDS-defining Event and/or CD4 (Cluster of Differentiation 4) Counts Below 200 Cells/mm³. ANRS 146 OPTIMAL.

Completed
Phase of Trial: Phase III

Latest Information Update: 03 Oct 2016

At a glance

  • Drugs Maraviroc (Primary) ; Efavirenz; Fosamprenavir; Ritonavir
  • Indications HIV-1 infections
  • Focus Therapeutic Use
  • Acronyms OPTIMAL
  • Most Recent Events

    • 07 Jun 2017 Biomarkers information updated
    • 11 Jul 2016 Status changed from active, no longer recruiting to completed.
    • 18 May 2016 The trial was completed in Spain (end date: 31 Mar 2016).
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