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Platelet Derived Growth Factor Receptor (PDGFR) Inhibitor Crenolanib in Children and Young Adults With Newly Diagnosed Diffuse Intrinsic Pontine Glioma or Recurrent High-Grade Glioma Including Diffuse Intrinsic Pontine Glioma.

Trial Profile

Platelet Derived Growth Factor Receptor (PDGFR) Inhibitor Crenolanib in Children and Young Adults With Newly Diagnosed Diffuse Intrinsic Pontine Glioma or Recurrent High-Grade Glioma Including Diffuse Intrinsic Pontine Glioma.

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 10 May 2022

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At a glance

  • Drugs Crenolanib (Primary)
  • Indications Anaplastic astrocytoma; Diffuse intrinsic pontine glioma; Glioblastoma; Glioma; Gliosarcoma; Oligodendroglioma
  • Focus Adverse reactions; Biomarker; Pharmacogenomic; Pharmacokinetics
  • Most Recent Events

    • 01 Apr 2022 Results assessing single-dose and steady-state serum pharmacokinetic samples from this study were collected and analyzed using a validated LC-ESI-MS/MS method, published in the Cancer Chemotherapy and Pharmacology.
    • 31 Oct 2016 Status changed from active, no longer recruiting to completed.
    • 21 Oct 2015 Planned End Date changed from 1 Sep 2015 to 1 Mar 2017 as reported by ClinicalTrials.gov record.
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