A Phase 3, Multicenter, Randomized, Active-Controlled Study to Investigate the Safety and Efficacy of PSI-7977 and Ribavirin for 12 Weeks Compared to Pegylated Interferon and Ribavirin for 24 Weeks in Treatment-Naive Patients With Chronic Genotype 2 or 3 HCV Infection.

Trial Profile

A Phase 3, Multicenter, Randomized, Active-Controlled Study to Investigate the Safety and Efficacy of PSI-7977 and Ribavirin for 12 Weeks Compared to Pegylated Interferon and Ribavirin for 24 Weeks in Treatment-Naive Patients With Chronic Genotype 2 or 3 HCV Infection.

Completed
Phase of Trial: Phase III

Latest Information Update: 23 Apr 2017

At a glance

  • Drugs Sofosbuvir (Primary) ; Peginterferon alfa-2a; Ribavirin
  • Indications Hepatitis C
  • Focus Registrational; Therapeutic Use
  • Acronyms FISSION
  • Sponsors Gilead Sciences
  • Most Recent Events

    • 12 Oct 2016 Results of a phylogenetic analysis from this and 10 other phase III Sofosbuvir trials, published in the Clinical Infectious Diseases.
    • 01 Sep 2015 Pooled analysis results published in the Journal of Hepatology.
    • 06 May 2014 Pooled analysis results of phase-III trials (Fission, Positron, Fusion, Valence and Neutrino) were presented at the Digestive Disease Week 2014.
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