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A Phase II Study of PCI-32765 for Patients With Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) Who Need Therapy and Are Older Than 65 or Have a 17p Deletion

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Trial Profile

A Phase II Study of PCI-32765 for Patients With Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Lymphoma (SLL) Who Need Therapy and Are Older Than 65 or Have a 17p Deletion

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 01 Mar 2024

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At a glance

  • Drugs Ibrutinib (Primary)
  • Indications Chronic lymphocytic leukaemia
  • Focus Therapeutic Use

    • Most Recent Events

    • 14 Jun 2023 Results assessing frequency and time to detection of BTK and PLCG2 mutations in peripheral blood samples across 5 clinical trials (NCT01500733, NCT01578707, NCT01722487, NCT01744691 and NCT02264574) published in the Clinical Cancer Research
    • 09 May 2023 Results of subgroup analysis (n=48; NCT02337829 and n=73; NCT01500733) assessing the role of CD49d for response to Bruton's tyrosine kinase inhibitors (BTKis) in patients with chronic lymphocytic leukemia published in the Clinical Cancer Research
    • 01 Feb 2022 Results of pooled analysis of 4 studies assessing (NCT01500733, NCT01722487, NCT02264574 and NCT02048813) long-term efficacy and safety of first-line ibrutinib-based therapy in patients with CLL bearing TP53 aberrations were published in the British Journal of Haematology.
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