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A Double-Blind, Placebo-Controlled Parallel-Group Study in Preclinical PSEN1 E280A Mutation Carriers Randomized to Crenezumab or Placebo, and in Non-Randomized, Placebo-Treated Non-Carriers From the Same Kindred, to Evaluate the Efficacy and Safety of Crenezumab in the Treatment of Autosomal-Dominant Alzheimer's Disease

Trial Profile

A Double-Blind, Placebo-Controlled Parallel-Group Study in Preclinical PSEN1 E280A Mutation Carriers Randomized to Crenezumab or Placebo, and in Non-Randomized, Placebo-Treated Non-Carriers From the Same Kindred, to Evaluate the Efficacy and Safety of Crenezumab in the Treatment of Autosomal-Dominant Alzheimer's Disease

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 25 Sep 2023

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At a glance

  • Drugs Crenezumab (Primary) ; Crenezumab (Primary)
  • Indications Alzheimer's disease
  • Focus Therapeutic Use
  • Acronyms API ADAD
  • Sponsors Genentech
  • Most Recent Events

    • 20 Jul 2023 Status changed from active, no longer recruiting to completed.
    • 20 Jul 2023 Results assessing the safety and efficacy of the investigational product crenezumab presented at the Alzheimer's Association International Conference 2023
    • 20 Jul 2023 Results comparing Impact of reference regions on longitudinal florbetapir PET SUVR changes from this study presented at the Alzheimer's Association International Conference 2023
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