Evaluation of the Antihyperalgesic Effect of Tapentadol in Two Human Experimental Models of: 1) Cold and Mechanical (Pinprick) Hyperalgesia Evoked by Topical Menthol Applied at High-concentration [40%], 2) Heat and Mechanical (Pinprick) Hyperalgesia by Topical Applied Capsaicin [0.6%].

Trial Profile

Evaluation of the Antihyperalgesic Effect of Tapentadol in Two Human Experimental Models of: 1) Cold and Mechanical (Pinprick) Hyperalgesia Evoked by Topical Menthol Applied at High-concentration [40%], 2) Heat and Mechanical (Pinprick) Hyperalgesia by Topical Applied Capsaicin [0.6%].

Discontinued
Phase of Trial: Phase I

Latest Information Update: 01 Sep 2016

At a glance

  • Drugs Tapentadol (Primary) ; Capsaicin; Menthol
  • Indications Hyperalgesia; Pain
  • Focus Pharmacodynamics; Proof of concept
  • Most Recent Events

    • 01 Sep 2016 Primary end point (thermal pain thresholds) has not been met.
    • 01 Sep 2016 Primary end point (mechanical pain sensitivity) has not been met.
    • 11 Oct 2012 Planned end date changed from 1 Mar 2013 to 1 Jun 2013 as reported by ClinicalTrials.gov.
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