Randomized, Phase II Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Patients With Advanced Melanoma (KEYNOTE 002)

Trial Profile

Randomized, Phase II Study of Pembrolizumab (MK-3475) Versus Chemotherapy in Patients With Advanced Melanoma (KEYNOTE 002)

Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 26 Sep 2017

At a glance

  • Drugs Pembrolizumab (Primary) ; Carboplatin; Dacarbazine; Paclitaxel; Temozolomide
  • Indications Malignant melanoma
  • Focus Registrational; Therapeutic Use
  • Acronyms KEYNOTE-002
  • Sponsors Merck Sharp & Dohme
  • Most Recent Events

    • 26 Sep 2017 Primary endpoint (Overall Survival (OS)) for both Arm 1-Pembrolizumab 2 mg/kg versus investigator-choice chemotherapy and Arm 2 -Pembrolizumab 10 mg/kg versus investigator-choice chemotherapy has not been met, according to results published in the European Journal of Cancer.
    • 26 Sep 2017 Primary endpoint (Progression-free Survival (PFS)) for both Arm 1-Pembrolizumab 2 mg/kg versus investigator-choice chemotherapy and Arm 2 -Pembrolizumab 10 mg/kg versus investigator-choice chemotherapy has been met, according to results published in the European Journal of Cancer.
    • 26 Sep 2017 Results assessing pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory advanced melanoma, were published in the European Journal of Cancer.
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