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A Double-Blind, Placebo-Controlled, Randomized, Multicenter Phase III Study Evaluating the Efficacy and Safety of Pertuzumab in Combination With Trastuzumab and Chemotherapy in Patients With HER2-Positive Metastatic Gastroesophageal Junction and Gastric Cancer

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Trial Profile

A Double-Blind, Placebo-Controlled, Randomized, Multicenter Phase III Study Evaluating the Efficacy and Safety of Pertuzumab in Combination With Trastuzumab and Chemotherapy in Patients With HER2-Positive Metastatic Gastroesophageal Junction and Gastric Cancer

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 13 Dec 2022

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At a glance

  • Drugs Pertuzumab (Primary) ; Capecitabine; Cisplatin; Fluoropyrimidine derivatives; Fluorouracil; Trastuzumab
  • Indications Adenocarcinoma; Gastric cancer; HER2 positive breast cancer; Oesophageal cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms JACOB
  • Sponsors Chugai Pharmaceutical; Roche

    • Most Recent Events

    • 22 Nov 2022 Results of post-hoc analysis published in the Clinical Cancer Research.
    • 13 Sep 2022 Results presented at the 47th European Society for Medical Oncology Congress
    • 21 Nov 2020 This study has been discontinued in Italy, according to European Clinical Trials Database record.
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