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A Phase IIIb, Double-Blind, Placebo-Controlled, Multicenter, Parallel Group, Extension Trial to Evaluate the Safety and Tolerability of Oral Cladribine in Subjects with Relapsing-Remitting Multiple Sclerosis Who Have Completed Trial 25643 (CLARITY)

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Trial Profile

A Phase IIIb, Double-Blind, Placebo-Controlled, Multicenter, Parallel Group, Extension Trial to Evaluate the Safety and Tolerability of Oral Cladribine in Subjects with Relapsing-Remitting Multiple Sclerosis Who Have Completed Trial 25643 (CLARITY)

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 28 Jun 2022

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At a glance

  • Drugs Cladribine (Primary)
  • Indications Multiple sclerosis
  • Focus Adverse reactions
  • Acronyms CLARITY EXT; CLARITY EXTENSION
  • Sponsors EMD Serono

    • Most Recent Events

    • 01 Jul 2022 Results assessing treatment durability of cladribine tablets beyond 2 years, published in the Multiple Sclerosis Journal
    • 27 Jun 2022 Results assessing prevalence estimator of Expanded Disability Status Scale (EDSS) improvement over time in patients treated with cladribine tablets in the phase III CLARITY extension trial, published in the European Journal of Neurology.
    • 01 Jan 2022 Results of post-hoc analysis frequency and severity of relapses in patients treated with CladT versus placebo (CLARITY & CLARITY EXT) were published in the Multiple Sclerosis Journal.
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