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Effect of ivabradine versus placebo on cardiac function, exercise capacity, and neuroendocrine activation in patients with Chronic Heart Failure with Preserved left ventricular Ejection Fraction An 8-month, randomised double-blind, placebo controlled, international, multicentre study.

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Trial Profile

Effect of ivabradine versus placebo on cardiac function, exercise capacity, and neuroendocrine activation in patients with Chronic Heart Failure with Preserved left ventricular Ejection Fraction An 8-month, randomised double-blind, placebo controlled, international, multicentre study.

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 11 Jun 2019

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At a glance

  • Drugs Ivabradine (Primary)
  • Indications Chronic heart failure
  • Focus Proof of concept; Therapeutic Use
  • Acronyms EDIFY
  • Sponsors IRIS; Servier

    • Most Recent Events

    • 30 Apr 2017 Primary endpoint (Echo-Doppler E/e ratio) has not been met, according to the results published in the European Journal of Heart Failure
    • 30 Apr 2017 Primary endpoint (B-type natriuretic peptide levels (NT-proBNP)) has not been met, according to the results published in the European Journal of Heart Failure
    • 30 Apr 2017 Primary endpoint (Six-minute walking distance) has not been met, according the results published in the European Journal of Heart Failure
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