A 2-part Phase III Randomized, Open Label, Multicenter Study of LGX818 Plus MEK162 Versus Vemurafenib and LGX818 Monotherapy in Patients With Unresectable or Metastatic BRAF V600 Mutant Melanoma.

Trial Profile

A 2-part Phase III Randomized, Open Label, Multicenter Study of LGX818 Plus MEK162 Versus Vemurafenib and LGX818 Monotherapy in Patients With Unresectable or Metastatic BRAF V600 Mutant Melanoma.

Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 12 Sep 2017

At a glance

  • Drugs Binimetinib (Primary) ; Encorafenib (Primary) ; Vemurafenib
  • Indications Malignant melanoma
  • Focus Registrational; Therapeutic Use
  • Acronyms COLUMBUS
  • Sponsors Array BioPharma; Novartis
  • Most Recent Events

    • 12 Sep 2017 Results from part-2 of the study, presented at the 42nd European Society for Medical Oncology Congress.
    • 12 Sep 2017 Results assessing hospitalization rates in Part 1 of the study (n=577) presented at the 42nd European Society for Medical Oncology Congress
    • 12 Sep 2017 Results assessing patient-reported health-related QoL in Part 1 of the study (n=577) presented at the 42nd European Society for Medical Oncology Congress
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