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Randomized Phase II Study for Evaluation of Efficacy and Safety of Maintenance Treatment With 5-FU/FA Plus Panitumumab vs. 5-FU/FA Alone After Prior Induction Treatment With mFOLFOX6 Plus Panitumumab and Re-induction With mFOLFOX6 Plus Panitumumab in Case of Progression for First-line Treatment of Patients With Metastatic Colorectal Cancer

Trial Profile

Randomized Phase II Study for Evaluation of Efficacy and Safety of Maintenance Treatment With 5-FU/FA Plus Panitumumab vs. 5-FU/FA Alone After Prior Induction Treatment With mFOLFOX6 Plus Panitumumab and Re-induction With mFOLFOX6 Plus Panitumumab in Case of Progression for First-line Treatment of Patients With Metastatic Colorectal Cancer

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 15 Dec 2023

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At a glance

  • Drugs Panitumumab (Primary) ; Fluorouracil; Folinic acid; Oxaliplatin
  • Indications Carcinoma; Colorectal cancer
  • Focus Therapeutic Use
  • Acronyms PanaMa
  • Most Recent Events

    • 24 Oct 2023 Results assessing the systemic proteome of CMSs from patients with RAS wild-type mCRC receiving fluorouracil and folinic acid with or without panitumumab (Pmab) after Pmab + mFOLFOX6 induction within the randomized phase II PanaMa trial, presented at the 48th European Society for Medical Oncology Congress.
    • 28 Jun 2023 Results of prespecified secondary analysis of Health-related quality of life , published in the European Journal of Cancer
    • 19 Jun 2023 Results of pooled analysis data pooled analysis of Valentino, Panama, MACRO-2, COIN-B trials published in the European Journal of Cancer
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