An Open-Label, Multicenter, Phase 1b Study of JNJ-54767414 (HuMax CD38) (Anti-CD38 Monoclonal Antibody) in Combination With Backbone Regimens for the Treatment of Subjects With Multiple Myeloma

Trial Profile

An Open-Label, Multicenter, Phase 1b Study of JNJ-54767414 (HuMax CD38) (Anti-CD38 Monoclonal Antibody) in Combination With Backbone Regimens for the Treatment of Subjects With Multiple Myeloma

Recruiting
Phase of Trial: Phase I

Latest Information Update: 25 Jun 2017

At a glance

  • Drugs Daratumumab (Primary) ; Bortezomib; Carfilzomib; Dexamethasone; Dexamethasone; Lenalidomide; Melphalan; Pomalidomide; Prednisone; Prednisone; Thalidomide
  • Indications Multiple myeloma
  • Focus Adverse reactions; Registrational
  • Acronyms EQUULEUS
  • Sponsors Janssen Research & Development
  • Most Recent Events

    • 25 Jun 2017 Results (n=22) assessing the tolerability and efficacy of Daratumumab in combination with carfilzomib, lenalidomide, and dexamethasone in patients with newly diagnosed multiple myeloma presented the 22nd Congress of the European Haematology Association
    • 16 Jun 2017 According to a Genmab media release, based on the data from this (EQUULEUS) study, the U.S. FDA has approved DARZALEX (daratumumab) in combination with pomalidomide and dexamethasone for the treatment of patients with multiple myeloma who have received at least two prior therapies including lenalidomide and a proteasome inhibitor.
    • 06 Jun 2017 Results (n=22) assessing the safety and efficacy of Daratumumab in combination with carfilzomib, lenalidomide, and dexamethasone in patients with newly diagnosed multiple myeloma, presented at the 53rd Annual Meeting of the American Society of Clinical Oncology.
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