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Phase III Study of Palbociclib in Combination With Exemestane or Fulvestrant vs. Chemotherapy (Capecitabine) in Hormonal Receptor Positive/HER2 Negative Metastatic Breast Cancer Patients With Resistance to Aromatase Inhibitors

Trial Profile

Phase III Study of Palbociclib in Combination With Exemestane or Fulvestrant vs. Chemotherapy (Capecitabine) in Hormonal Receptor Positive/HER2 Negative Metastatic Breast Cancer Patients With Resistance to Aromatase Inhibitors

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 12 Feb 2024

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At a glance

  • Drugs Exemestane (Primary) ; Fulvestrant (Primary) ; Palbociclib (Primary) ; Capecitabine
  • Indications Advanced breast cancer; HER2 negative breast cancer
  • Focus Therapeutic Use
  • Acronyms PEARL
  • Most Recent Events

    • 09 Dec 2023 Results assessing Body Mass Index and Treatment Efficacy in advanced Luminal Breast Cancer presented at the 46th Annual San Antonio Breast Cancer Symposium
    • 06 Jun 2023 Results investigating the prognostic and predictive value of cytoplasmic and nuclear isoforms of cyclin E in metastatic breast cancer, presented at the 59th Annual Meeting of the American Society of Clinical Oncology
    • 07 Feb 2023 Tumor samples of 455 patients were used for mRNA gene expression profiling and correlation with progression-free-survival (PFS), published in the Clinical Cancer Research
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