A Phase 1/2 Study Exploring the Safety, Tolerability, and Efficacy of Pembrolizumab (MK-3475) in Combination With Epacadostat (INCB024360) in Subjects With Selected Cancers (KEYNOTE-037/ ECHO-202)

Trial Profile

A Phase 1/2 Study Exploring the Safety, Tolerability, and Efficacy of Pembrolizumab (MK-3475) in Combination With Epacadostat (INCB024360) in Subjects With Selected Cancers (KEYNOTE-037/ ECHO-202)

Recruiting
Phase of Trial: Phase I/II

Latest Information Update: 24 Jun 2017

At a glance

  • Drugs Epacadostat (Primary) ; Pembrolizumab (Primary)
  • Indications Adenocarcinoma; Advanced breast cancer; B cell lymphoma; Colorectal cancer; Head and neck cancer; Non-small cell lung cancer; Ovarian cancer; Renal cell carcinoma; Solid tumours; Squamous cell cancer; Urogenital cancer
  • Focus Adverse reactions; Proof of concept; Therapeutic Use
  • Acronyms ECHO-202; KEYNOTE-037
  • Sponsors Incyte Corporation; Merck & Co
  • Most Recent Events

    • 10 Jun 2017 Biomarkers information updated
    • 06 Jun 2017 Preliminary phase I/II results in patients with advanced urothelial carcinoma ( n=40 [phase I, n = 5; phase II, n = 35]) presented at the 53rd Annual Meeting of the American Society of Clinical Oncology
    • 06 Jun 2017 Preliminary phase I/II results in patients with renal cell carcinoma (n=33, phase I n=11 and phase II n=22) presented at the 53rd Annual Meeting of the American Society of Clinical Oncology
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