A Phase 2 Clinical Trial of Nivolumab, or Nivolumab Combinations in Recurrent and Metastatic Microsatellite High (MSI-H) and Non-MSI-H Colon Cancer

Trial Profile

A Phase 2 Clinical Trial of Nivolumab, or Nivolumab Combinations in Recurrent and Metastatic Microsatellite High (MSI-H) and Non-MSI-H Colon Cancer

Recruiting
Phase of Trial: Phase II

Latest Information Update: 01 Aug 2017

At a glance

  • Drugs Nivolumab (Primary) ; BMS 986016; Cobimetinib; Daratumumab; Ipilimumab
  • Indications Colorectal cancer
  • Focus Therapeutic Use
  • Acronyms CheckMate 142
  • Sponsors Bristol-Myers Squibb
  • Most Recent Events

    • 01 Aug 2017 Results published in the Bristol-Myers Squibb media release
    • 01 Aug 2017 According to a Bristol-Myers Squibb media release, Based on the data from this trial the U.S. Food and Drug Administration (FDA) has approved Opdivo (nivolumab) injection for intravenous use for the treatment of adult and pediatric (12 years and older) patients with microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) metastatic colorectal cancer (mCRC) that has progressed following treatment with a fluoropyrimidine, oxaliplatin, and irinotecan.
    • 19 Jul 2017 Results (n=74, enrolled between March 12, 2014, and March 16, 2016) published in the Lancet Oncology
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