Phase II, Open Label, Single-arm Study to Assess Safety and Efficacy of AZD9291 in Patients With Locally Advanced/Metastatic NSCLC Whose Disease Has Progressed With Previous EGFR TKI and Whose Tumours Are EGFR and T790M Mutation Positive

Trial Profile

Phase II, Open Label, Single-arm Study to Assess Safety and Efficacy of AZD9291 in Patients With Locally Advanced/Metastatic NSCLC Whose Disease Has Progressed With Previous EGFR TKI and Whose Tumours Are EGFR and T790M Mutation Positive

Completed
Phase of Trial: Phase II

Latest Information Update: 12 Sep 2017

At a glance

  • Drugs Osimertinib (Primary)
  • Indications Non-small cell lung cancer
  • Focus Registrational; Therapeutic Use
  • Acronyms AURA2
  • Sponsors AstraZeneca
  • Most Recent Events

    • 12 Sep 2017 Results (data cut off: 1 Nov, 2016; n = 411) of a pooled analysis from AURA extension AURA2 studies assessing overall survival in patients with EGFR T790M-positive advanced non-small cell lung cancer treated with osimertinib, presented at the 42nd European Society for Medical Oncology Congress.
    • 01 Aug 2017 Results of EGFR mutation analysis data from two studies (AURA2 and AURA extension) published in the Journal of Thoracic Oncology
    • 06 Jun 2017 Results of population pharmacokinetic and pharmacodynamic analysis using data from three AURA studies (AURA, AURA 2 and AURA 3) presented at the 53rd Annual Meeting of the American Society of Clinical Oncology
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