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A Multicenter Extension Study to Evaluate the Long-Term Safety and Durability of the Therapeutic Effect of LUM001, an Apical Sodium-Dependent Bile Acid Transporter Inhibitor (ASBTi), in the Treatment of Cholestatic Liver Disease in Pediatric Subjects With Alagille Syndrome

Trial Profile

A Multicenter Extension Study to Evaluate the Long-Term Safety and Durability of the Therapeutic Effect of LUM001, an Apical Sodium-Dependent Bile Acid Transporter Inhibitor (ASBTi), in the Treatment of Cholestatic Liver Disease in Pediatric Subjects With Alagille Syndrome

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 25 May 2023

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At a glance

  • Drugs Maralixibat (Primary)
  • Indications Alagille syndrome; Cholestasis; Liver disorders
  • Focus Adverse reactions
  • Acronyms IMAGINE-II
  • Sponsors Mirum Pharmaceuticals; Shire; Takeda
  • Most Recent Events

    • 19 May 2023 According to a Mirum Pharmaceuticals media release, integrated analysis of 2 studies presented at the 55th European Society for Pediatric, Gastroenterology, Hepatology, and Nutrition (ESPGHAN) Annual Meeting.
    • 05 Oct 2022 According to a Mirum Pharmaceuticals media release, a 4-year analysis data will be presented during the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN) Annual Meeting 2022.
    • 24 Jun 2022 According to a Mirum Pharmaceuticals media release, data from this study presented at the 54th Annual European Society for Paediatric Gastroenterology, Hepatology, and Nutrition Annual Meeting (ESPGHAN)
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