A Phase 3 Multicenter, Double-Blind, Randomized, Active Comparator-Controlled Clinical Trial to Evaluate the Safety and Efficacy of Doravirine (MK-1439) 100 mg Once Daily Versus Darunavir 800 mg Once Daily Plus Ritonavir 100 mg Once Daily, Each in Combination With TRUVADA or EPZICOM/KIVEXA, in Treatment-Naive HIV-1 Infected Subjects

Trial Profile

A Phase 3 Multicenter, Double-Blind, Randomized, Active Comparator-Controlled Clinical Trial to Evaluate the Safety and Efficacy of Doravirine (MK-1439) 100 mg Once Daily Versus Darunavir 800 mg Once Daily Plus Ritonavir 100 mg Once Daily, Each in Combination With TRUVADA or EPZICOM/KIVEXA, in Treatment-Naive HIV-1 Infected Subjects

Active, no longer recruiting
Phase of Trial: Phase III

Latest Information Update: 04 Aug 2017

At a glance

  • Drugs Doravirine (Primary) ; Darunavir; Emtricitabine/tenofovir disoproxil fumarate; Lamivudine/abacavir; Ritonavir
  • Indications HIV-1 infections
  • Focus Registrational; Therapeutic Use
  • Acronyms DRIVE-FORWARD
  • Sponsors Merck & Co; Merck Sharp & Dohme
  • Most Recent Events

    • 01 Aug 2017 Planned End Date changed from 23 Nov 2018 to 18 Sep 2017.
    • 16 Feb 2017 Results presented at the 24th Conference on Retroviruses and Opportunistic Infections
    • 14 Feb 2017 Primary endpoint (Percentage of participants achieving HIV-1 RNA 50 copies/mL at Week 48) has been met, according to a Merck media release.
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