A Phase 1a/1b Dose Escalation and Expansion Trial of TTI-621, a Novel Biologic Targeting CD47, in Subjects With Relapsed or Refractory Hematologic Malignancies and Selected Solid Tumors

Trial Profile

A Phase 1a/1b Dose Escalation and Expansion Trial of TTI-621, a Novel Biologic Targeting CD47, in Subjects With Relapsed or Refractory Hematologic Malignancies and Selected Solid Tumors

Recruiting
Phase of Trial: Phase I

Latest Information Update: 16 Sep 2017

At a glance

  • Drugs TTI 621 (Primary) ; Nivolumab; Rituximab
  • Indications Acute lymphoblastic leukaemia; Haematological malignancies; Hodgkin's disease; Lymphoma; Small cell lung cancer; Solid tumours
  • Focus Adverse reactions; First in man
  • Sponsors Trillium Therapeutics
  • Most Recent Events

    • 11 Aug 2017 According to a Trillium Therapeutics media release, Additional data expected in the second half of 2017.
    • 19 Jun 2017 Protocol amended with inclusion of patients with solid tumor, change in study design, treatment arm and primary end point revised.
    • 19 Jun 2017 Planned number of patients changed from 186 to 270.
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