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An Exploratory Pilot Study of Nab-paclitaxel Based Induction Chemotherapy Followed by Response-Stratified Locoregional Therapy for Patients With Stage III and IV HPV-Related Oropharyngeal Cancer - the OPTIMA HPV Trial

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Trial Profile

An Exploratory Pilot Study of Nab-paclitaxel Based Induction Chemotherapy Followed by Response-Stratified Locoregional Therapy for Patients With Stage III and IV HPV-Related Oropharyngeal Cancer - the OPTIMA HPV Trial

Status: Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 19 Sep 2023

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At a glance

  • Drugs Paclitaxel (Primary) ; Carboplatin; Cisplatin; Fluorouracil; Hydroxycarbamide
  • Indications Head and neck cancer; Human papillomavirus infections; Oropharyngeal cancer; Squamous cell cancer
  • Focus Therapeutic Use
  • Acronyms OPTIMA

    • Most Recent Events

    • 28 Aug 2023 Planned End Date changed from 1 Dec 2022 to 1 Dec 2025.
    • 08 Feb 2022 Planned End Date changed from 1 Dec 2021 to 1 Dec 2022.
    • 31 May 2020 Results of long-term follow-up from this study and retrospective review of additional patients treated subsequently per OPTIMA outline (n=106) presented at the 56th Annual Meeting of the American Society of Clinical Oncology.
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