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A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Of The Safety, Clinical Activity And Pharmacokinetics Of Bosutinib (PF-05208763) Versus Placebo In Subjects With Autosomal Dominant Polycystic Kidney Disease (ADPKD)

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Trial Profile

A Phase 2, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study Of The Safety, Clinical Activity And Pharmacokinetics Of Bosutinib (PF-05208763) Versus Placebo In Subjects With Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 06 Nov 2021

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At a glance

  • Drugs Bosutinib (Primary)
  • Indications Autosomal dominant polycystic kidney disease
  • Focus Therapeutic Use
  • Sponsors Pfizer

    • Most Recent Events

    • 01 Nov 2017 According to results published in the Journal of the American Society of Nephrology, a protocol was amended to reduce doses of 24 patients who initially received bosutinib at 400 mg/d to 200 mg/d.
    • 01 Nov 2017 Primary endpoint of annualized rate of kidney enlargement in patients treated for more than or equal to 2 weeks has been met, according to results published in the Journal of the American Society of Nephrology.
    • 01 Nov 2017 Results published in the Journal of the American Society of Nephrology
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