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A randomised, double-blind, placebo-controlled, parallel-group, multi-centre 24-week study to evaluate the efficacy and safety of mepolizumab adjunctive therapy in subjects with severe eosinophilic asthma on markers of asthma control - the MUSCA study

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Trial Profile

A randomised, double-blind, placebo-controlled, parallel-group, multi-centre 24-week study to evaluate the efficacy and safety of mepolizumab adjunctive therapy in subjects with severe eosinophilic asthma on markers of asthma control - the MUSCA study

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 06 Sep 2023

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At a glance

  • Drugs Mepolizumab (Primary)
  • Indications Asthma; Eosinophilia
  • Focus Registrational; Therapeutic Use
  • Acronyms MUSCA
  • Sponsors GlaxoSmithKline; GSK

    • Most Recent Events

    • 01 Mar 2021 Results of post hoc meta analysis of data from the Phase III MENSA and MUSCA studies presented at the 2021 Annual Meeting of the American Academy of Allergy, Asthma and Immunology
    • 16 Mar 2020 Results of a post hoc analysis of data from DREAM, MENSA and MUSCA Efficacy of Mepolizumab Stratified by Baseline Blood Eosinophil Count, presented at the 2020 Annual Meeting of the American Academy of Allergy, Asthma and Immunology
    • 16 Mar 2020 Results (n=1189) of post-hoc pooled analysis of four studies ( DREAM, MENSA, SIRIUS, and MUSCA ) assessing impact of mepolizumab on clinically significant exacerbations and health-related quality of life (HRQoL) in patients with severe eosinophilic asthma and upper respiratory comorbidities, published at the 2020 Annual Meeting of the American Academy of Allergy, Asthma and Immunology.
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