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A Randomized, Single-Blind, Multicenter Phase 2 Study to Evaluate the Activity of 2 Dose Levels of Imetelstat in Subjects With Intermediate-2 or High-Risk Myelofibrosis (MF) Relapsed/Refractory to Janus Kinase (JAK) Inhibitor

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Trial Profile

A Randomized, Single-Blind, Multicenter Phase 2 Study to Evaluate the Activity of 2 Dose Levels of Imetelstat in Subjects With Intermediate-2 or High-Risk Myelofibrosis (MF) Relapsed/Refractory to Janus Kinase (JAK) Inhibitor

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 28 Jan 2022

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At a glance

  • Drugs Imetelstat (Primary)
  • Indications Essential thrombocythaemia; Myelofibrosis; Polycythaemia vera
  • Focus Registrational; Therapeutic Use
  • Acronyms IMbark
  • Sponsors Geron Corporation; Janssen Research & Development; Janssen-Cilag

    • Most Recent Events

    • 01 Jan 2022 Results (n=57) from NCT02426086 comapring overall survival with imetelstat in relapsed/refractory myelofibrosis patients with real-world data study (n=38 ) treated with best available therapy, published in the Journal of Neuro-Ophthalmology
    • 11 Oct 2021 Results published in the Geron Corporation Media Release.
    • 11 Oct 2021 According to a Geron Corporation media release, overall survival data compared with real world data were published in the Annals of Hematology.
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