PHASE IA/IB, OPEN-LABEL, MULTICENTER, MULTIPLE ASCENDING DOSE STUDY FOLLOWED BY AN EXTENSION PHASE TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS AND ACTIVITY OF RO6927005, AN ANTI-MESOTHELIN (MSLN) RECOMBINANT CYTOLYTIC FUSION PROTEIN (cFP), ADMINISTERED EITHER ALONE (PART A) OR IN COMBINATION WITH GEMCITABINE AND NAB-PACLITAXEL (PART B) IN PATIENTS WITH MESOTHELIN-POSITIVE METASTATIC AND/OR LOCALLY ADVANCED MALIGNANT SOLID TUMORS

Trial Profile

PHASE IA/IB, OPEN-LABEL, MULTICENTER, MULTIPLE ASCENDING DOSE STUDY FOLLOWED BY AN EXTENSION PHASE TO EVALUATE THE SAFETY, TOLERABILITY, PHARMACOKINETICS AND ACTIVITY OF RO6927005, AN ANTI-MESOTHELIN (MSLN) RECOMBINANT CYTOLYTIC FUSION PROTEIN (cFP), ADMINISTERED EITHER ALONE (PART A) OR IN COMBINATION WITH GEMCITABINE AND NAB-PACLITAXEL (PART B) IN PATIENTS WITH MESOTHELIN-POSITIVE METASTATIC AND/OR LOCALLY ADVANCED MALIGNANT SOLID TUMORS

Discontinued
Phase of Trial: Phase I

Latest Information Update: 28 Jul 2016

At a glance

  • Drugs RO 6927005 (Primary) ; Gemcitabine; Paclitaxel
  • Indications Solid tumours
  • Focus Adverse reactions; First in man
  • Sponsors Roche
  • Most Recent Events

    • 08 Jun 2016 Status changed from completed to discontinued.
    • 01 Oct 2015 Status changed from recruiting to completed as reported by ClinicalTrials.gov.
    • 31 Jul 2015 Planned End Date changed from 1 Jan 2018 to 1 Aug 2015 as reported by ClinicalTrials.gov
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