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A Phase 2b, Open-Label, Single-Arm Study of Selinexor (KPT-330) Plus Low-‑Dose Dexamethasone (Sd) in Patients With Multiple Myeloma Previously Treated With Lenalidomide, Pomalidomide, Bortezomib, Carfilzomib, and an Anti-CD38 Monoclonal Antibody (mAb) Daratumumab, and Refractory to Prior Treatment With Glucocorticoids, an Immunomodulatory Agent, a Proteasome Inhibitor, and an the Anti-CD38 mAb Daratumumab

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Trial Profile

A Phase 2b, Open-Label, Single-Arm Study of Selinexor (KPT-330) Plus Low-‑Dose Dexamethasone (Sd) in Patients With Multiple Myeloma Previously Treated With Lenalidomide, Pomalidomide, Bortezomib, Carfilzomib, and an Anti-CD38 Monoclonal Antibody (mAb) Daratumumab, and Refractory to Prior Treatment With Glucocorticoids, an Immunomodulatory Agent, a Proteasome Inhibitor, and an the Anti-CD38 mAb Daratumumab

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 11 Dec 2023

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At a glance

  • Drugs Dexamethasone (Primary) ; Selinexor (Primary)
  • Indications Multiple myeloma; Plasmacytoma
  • Focus Registrational; Therapeutic Use
  • Acronyms STORM
  • Sponsors Karyopharm Therapeutics

    • Most Recent Events

    • 06 Dec 2023 According to an Antengene Corporation media release, the Pharmaceutical Administration Bureau of Macau has approved a NDA for XPOVIO (selinexor), applicable in combination with dexamethasone (Xd), for the treatment of adult patients with relapsed and/or refractory multiple myeloma (R/R MM) who have received at least four prior therapies and whose disease is refractory to at least two proteasome inhibitors (PIs), two immunomodulatory agents (IMiDs), an anti-CD38 monoclonal antibody.
    • 26 Sep 2023 According to a Karyopharm Therapeutics media release, data from this trial will be presented at the 2023 International Myeloma Society (IMS) Annual Meeting, being held September 27-30 in Athens, Greece.
    • 15 Jun 2023 Results of pooled analysis from 3 studies [MonumenTAL-1 (NCT03399799/NCT04636552), STORM (NCT02336815) and DREAMM-2 (NCT03525678)] comparing the effectiveness of talquetamab vs sel-dex and vs belamaf presented at the 28th Congress of the European Haematology Association.
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