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A Phase 1, Open-label, Multicenter Trial of Oral Azacitidine (CC-486) Plus R-CHOP in Subjects With High Risk (IPI 3 or More) Previously Untreated Diffuse Large B-cell Lymphoma or Grade 3B Follicular Lymphoma

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Trial Profile

A Phase 1, Open-label, Multicenter Trial of Oral Azacitidine (CC-486) Plus R-CHOP in Subjects With High Risk (IPI 3 or More) Previously Untreated Diffuse Large B-cell Lymphoma or Grade 3B Follicular Lymphoma

Status: Completed
Phase of Trial: Phase I

Latest Information Update: 06 Nov 2021

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At a glance

  • Drugs Azacitidine (Primary) ; Cyclophosphamide; Doxorubicin; Filgrastim; Lenograstim; Pegfilgrastim; Prednisone; Rituximab; Vincristine
  • Indications Diffuse large B cell lymphoma; Follicular lymphoma; Lymphoma; Marginal zone B-cell lymphoma
  • Focus Adverse reactions
  • Sponsors Celgene Corporation

    • Most Recent Events

    • 24 Aug 2021 Results assessing safety and efficacy in patients with previously untreated DLBCL, grade 3B FL, or transformed lymphoma published in the Blood
    • 26 Aug 2020 Status changed from active, no longer recruiting to completed.
    • 11 Feb 2019 Planned End Date changed from 1 Mar 2020 to 1 Feb 2020.
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