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Phase 1b/2a Safety and Pharmacokinetic Study of G1T28 in Patients With Previously Treated Extensive Stage Small Cell Lung Cancer (SCLC) Receiving Topotecan Chemotherapy

Trial Profile

Phase 1b/2a Safety and Pharmacokinetic Study of G1T28 in Patients With Previously Treated Extensive Stage Small Cell Lung Cancer (SCLC) Receiving Topotecan Chemotherapy

Status: Discontinued
Phase of Trial: Phase I/II

Latest Information Update: 15 Dec 2023

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At a glance

  • Drugs Topotecan (Primary) ; Trilaciclib (Primary)
  • Indications Small cell lung cancer
  • Focus Adverse reactions; Proof of concept; Registrational
  • Sponsors G1 Therapeutics
  • Most Recent Events

    • 24 Oct 2023 Results assessing the occurrence of chemotherapy-induced myelosuppression events with standard of care chemotherapies for relapsed SCLC and supportive care interventions from NCT02454972, NCT02514447 and NCT02566993, presented at the 48th European Society for Medical Oncology Congress.
    • 16 Jul 2022 Results from NCT02514447 and other studies investigating the pharmacokinetic drug-drug interaction potential of trilaciclib, published in the Clinical Drug Investigation
    • 02 Jun 2022 Results from a post-hoc analysis of (NCT02499770 , NCT03041311 , NCT02514447 ) were presented in a poster at the 2022 American Society of Clinical Oncology (ASCO) annual meeting
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