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A Randomized, Double-blind, Sponsor Un-blinded, Placebo-controlled, Phase 2a Crossover Study to Evaluate the Effect of the TRPV4 Channel Blocker, GSK2798745, on Pulmonary Gas Transfer and Respiration in Patients With Congestive Heart Failure

Trial Profile

A Randomized, Double-blind, Sponsor Un-blinded, Placebo-controlled, Phase 2a Crossover Study to Evaluate the Effect of the TRPV4 Channel Blocker, GSK2798745, on Pulmonary Gas Transfer and Respiration in Patients With Congestive Heart Failure

Status: Completed
Phase of Trial: Phase II

Latest Information Update: 26 Aug 2023

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At a glance

  • Drugs GSK 2798745 (Primary)
  • Indications Heart failure
  • Focus Therapeutic Use
  • Sponsors GlaxoSmithKline; GSK
  • Most Recent Events

    • 30 Mar 2020 Primary endpoint (Change from Baseline in the diffusing capacity of the lung for carbon monoxide on pulmonary gas transfer after 7 days of treatment) has not been met, according results published in the European Journal of Heart Failure
    • 30 Mar 2020 Results published in the European Journal of Heart Failure
    • 28 Aug 2017 Status changed from active, no longer recruiting to completed.
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