A Randomized, Double-Blind, Active-Controlled, Phase 3 Study to Evaluate the Safety and Efficacy of CCX168 (Avacopan) in Patients with Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis Treated Concomitantly with Rituximab or Cyclophosphamide/Azathioprine

Trial Profile

A Randomized, Double-Blind, Active-Controlled, Phase 3 Study to Evaluate the Safety and Efficacy of CCX168 (Avacopan) in Patients with Anti-Neutrophil Cytoplasmic Antibody (ANCA)-Associated Vasculitis Treated Concomitantly with Rituximab or Cyclophosphamide/Azathioprine

Recruiting
Phase of Trial: Phase III

Latest Information Update: 28 Sep 2017

At a glance

  • Drugs Avacopan (Primary) ; Azathioprine; Cyclophosphamide; Cyclophosphamide; Prednisone; Rituximab
  • Indications Anti-neutrophil cytoplasmic antibody-associated vasculitis
  • Focus Therapeutic Use
  • Acronyms ADVOCATE
  • Sponsors ChemoCentryx
  • Most Recent Events

    • 08 Aug 2017 According to a ChemoCentryx media release, enrollment in this trial is expected to complete in mid-2018.
    • 09 Jan 2017 According to a ChemoCentryx media release, the trial design was discussed in detail with both the U.S. FDA and European Medicines Agency (EMA), and agreement was reached on the design and goals of the trial.
    • 23 Dec 2016 Planned End Date changed from 1 Apr 2020 to 1 Oct 2019.
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