A Phase 1/2a Trial to Evaluate the Safety/Tolerability and Immunogenicity of Homologous Ad26 Mosaic Vector Regimens or Ad26 Mosaic and MVA Mosaic Heterologous Vector Regimens, With High-Dose, Low-Dose or no Clade C gp140 Protein Plus Adjuvant for HIV Prevention

Trial Profile

A Phase 1/2a Trial to Evaluate the Safety/Tolerability and Immunogenicity of Homologous Ad26 Mosaic Vector Regimens or Ad26 Mosaic and MVA Mosaic Heterologous Vector Regimens, With High-Dose, Low-Dose or no Clade C gp140 Protein Plus Adjuvant for HIV Prevention

Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 24 Jul 2017

At a glance

  • Drugs HIV vaccine Ad26 ENVA-01 (Primary) ; MVA mosaic HIV vaccine-Crucell Holland (Primary) ; HIV gp140 vaccine
  • Indications HIV infections
  • Focus Adverse reactions; Pharmacodynamics
  • Acronyms APPROACH
  • Sponsors Janssen Vaccines and Prevention
  • Most Recent Events

    • 24 Jul 2017 According to Johnson & Johnson media release, vaccination schedules have been completed for all study participants and 12-month follow-up after the 4th dose is underway.
    • 24 Jul 2017 Early stage data published in a Johnson & Johnson Media Release.
    • 24 Jul 2017 According to Johnson & Johnson media release, early stage results from this trial were presented at the 9th IAS Conference on HIV Science (IAS 2017).
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