A Phase 2a, Open-Label Study to Evaluate the Safety, Pharmacokinetics and Efficacy of the Combination of AL-335 and Odalasvir, With or Without Simeprevir, in Treatment-Naïve Subjects With Genotype 1, 2 or 3 Chronic Hepatitis C Infection With or Without Compensated Child Pugh A Cirrhosis

Trial Profile

A Phase 2a, Open-Label Study to Evaluate the Safety, Pharmacokinetics and Efficacy of the Combination of AL-335 and Odalasvir, With or Without Simeprevir, in Treatment-Naïve Subjects With Genotype 1, 2 or 3 Chronic Hepatitis C Infection With or Without Compensated Child Pugh A Cirrhosis

Active, no longer recruiting
Phase of Trial: Phase II

Latest Information Update: 14 Nov 2017

At a glance

  • Drugs AL 335 (Primary) ; Odalasvir (Primary) ; Simeprevir (Primary)
  • Indications Hepatitis C
  • Focus Adverse reactions
  • Sponsors Alios BioPharma
  • Most Recent Events

    • 06 Nov 2017 Planned primary completion date changed from 30 Dec 2017 to 30 Jun 2018.
    • 24 Oct 2017 Results of this and other phase II study assessing virologic response presented at The Liver Meeting 2017: 68th Annual Meeting of the American Association for the Study of Liver Diseases.
    • 24 Oct 2017 Results assessing pharmacokinetics and dose selection of the direct anti-viral combination, presented at The Liver Meeting 2017: 68th Annual Meeting of the American Association for the Study of Liver Diseases
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