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A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of LY2951742 in Patients With Episodic Migraine - the EVOLVE-1 Study

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Trial Profile

A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of LY2951742 in Patients With Episodic Migraine - the EVOLVE-1 Study

Status: Completed
Phase of Trial: Phase III

Latest Information Update: 01 Dec 2023

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At a glance

  • Drugs Galcanezumab (Primary)
  • Indications Migraine
  • Focus Registrational; Therapeutic Use
  • Acronyms EVOLVE-1
  • Sponsors Eli Lilly and Company

    • Most Recent Events

    • 28 Nov 2023 Results of pooled post hoc analysis (n=462 from studies EVOLVE-1 and EVOLVE-2) assessing Effect of galcanezumab in women with episodic migraine meeting criteria for menstrually related migraine published in the Headache
    • 03 May 2023 Results of post hoc analysis (n=3348) assessing at population and individual patient levels, the sustained response of reduction in migraine headache days in patients with migraine treated with galcanezumab from two 6-month episodic migraine (EM; EVOLVE-1/EVOLVE-2), one 3-month chronic migraine (CM; REGAIN), and one 3-month treatment-resistant migraine (CONQUER) studies, published in the Headache.
    • 27 Apr 2023 Results of pooled analysis(n=1551 from 3 studies EVOLVE-1, EVOLVE-2, and CONQUER ) assessing Clinically meaningful improvement in disability (MIDAS score) in the absence of greater than 50% reductions in monthly migraine days with galcanezumab presented at the 75th Annual Meeting of the American Academy of Neurology 2023
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