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A Phase 1 Open-label Dose Escalation Study of CGX1321 in Subjects With Advanced Solid Tumors With Expansion in Advanced Gastrointestinal Tumors and Phase 1b Study of CGX1321 in Combination With Pembrolizumab in Subjects With Advanced Colorectal Cancer or in Combination With Encorafenib + Cetuximab in Subjects With BRAFV600E Mutated Advanced Colorectal Cancer

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Trial Profile

A Phase 1 Open-label Dose Escalation Study of CGX1321 in Subjects With Advanced Solid Tumors With Expansion in Advanced Gastrointestinal Tumors and Phase 1b Study of CGX1321 in Combination With Pembrolizumab in Subjects With Advanced Colorectal Cancer or in Combination With Encorafenib + Cetuximab in Subjects With BRAFV600E Mutated Advanced Colorectal Cancer

Status: Recruiting
Phase of Trial: Phase I

Latest Information Update: 04 Jan 2024

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At a glance

  • Drugs CGX 1321 (Primary) ; Cetuximab; Encorafenib; Pembrolizumab
  • Indications Adenocarcinoma; Cholangiocarcinoma; Colorectal cancer; Gastrointestinal cancer; Liver cancer; Oesophageal cancer; Pancreatic cancer; Solid tumours
  • Focus Adverse reactions; First in man
  • Acronyms Keynote 596
  • Sponsors Curegenix

    • Most Recent Events

    • 06 Jun 2023 Results ( As of January 1, 2023), presented at the 59th Annual Meeting of the American Society of Clinical Oncology
    • 11 Jan 2022 Planned End Date changed from 1 Dec 2022 to 1 Mar 2023.
    • 11 Jan 2022 Planned primary completion date changed from 1 Dec 2022 to 1 Mar 2023.
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